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Dr.

Philip Needleman

(
1939
–
2024
)
Pharmacia Corporation; Washington University in St. Louis
;
Creve Coeur, MO
Pharmacologist; Company research scientist; Educator
Area
Biological Sciences
Specialty
Medical Sciences
Elected
2015

Professor and Chairman of Department of Pharmacology, Washington University School of Medicine, St Louis. Chief Scientist and Head of R&D Monsanto/Searle/Pharmacia. Member NAS and IOM. Interim President of Donald Danforth Plant Science Center; Interim CEO of the St Louis Science Center.  

Discovered the first angiotensin receptor antagonist (hypertension); discovered first pass drug metabolism (nitroglycerin); discovered a new endocrine hormone system ANF (atriopeptin) a critical hormone that controls salt, water metabolism, blood pressure and cardiac performance (heart failure);discovered the existence and critical role of cox2 in inflammation and oncology. Industry: Discovered and developed widely used therapeutics in arthritis (cox2 inhibitors: Celebrex®, Bextra®,Parecoxib), heart failure (Eplerenone), and oncology (Sutent®).

 

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