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Professor

Paul Lawrence Modrich

Duke Medicine
Biochemist; Molecular biologist; Educator
Area
Biological Sciences
Specialty
Biochemistry, Biophysics, and Molecular Biology
Elected
2004
James B. Duke Professor of Biochemistry; Investigator, Howard Hughes Medical Institute. Established the molecular mechanism by which the DNA mismatch repair system prevents mutations. Assigned activities to bacterial and human mismatch repair proteins and demonstrated that tumor cells derived from patients with hereditary nonpolyposis colon cancer are defective in this reaction.
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