Per-Olof Berggren

Known for his work regarding the fundamental mechanisms regulating the stimulus-response coupling in the endocrine pancreas with seminal contributions within the fields of  insulin secreting pancreatic β-cell Ca²⁺ handling, phosphorylated inositol compounds and insulin receptor operated signaling. He has shown that the structure/function relationship in human islets is different from that in mouse. He has developed an in vivo experimental platform using the anterior chamber of the eye as a transplantation site and the cornea as a natural body window for imaging. This allows studies of human islet function and survival at single cell resolution and cures diabetes in rodents.