Jennifer Lippincott-Schwartz

Jennifer Lippincott-Schwartz has pioneered the use of green fluorescent protein technology for quantitative analysis and modeling of intracellular protein traffic and organelle biogenesis, providing novel insights into cell compartmentalization, protein trafficking and organelle inheritance. She created the photoactivatable GFP and co­developed the superresolution imaging technique of photoactivated localization microscopy (PALM). She introduced various PALM implementations to track single molecules and measure protein cluster patterns. She employed superresolution imaging to identify and image novel cellular structures, including HIV particles, acto­myosin contractile elements and dense matrices formed by ER tubules. She applied systems-level spectral imaging and analysis to reveal the organelle interactome.