James L. Manley

Julian Clarence Levi Professor of Life Sciences. Made important contributions to understanding eukaryotic gene expression. Identified the key protein factors and elucidated the mechanism of mRNA polyadenylation. Discovered the first alternative splicing factor (SR protein) and provided first direct evidence for RNA catalysis of mRNA splicing. Demonstrated unexpected links between RNA processing with transcription, DNA damage signaling and human disease, especially cancer and neurodegenerative ailments.