Gerald I. Shulman

Dr. Shulman's pioneering application of magnetic resonance spectroscopy has made it possible to directly examine intracellular glucose and lipid metabolism in humans for the first time. This has afforded a dynamic view of glucose and lipid metabolism not before possible in man. In a seminal series of studies his group has shown that decreased insulin-stimulated muscle glycogen synthesis, due to defects in insulin-stimulated glucose transport activity, is the major factor responsible for muscle insulin resistance in T2D, obesity and prediabetes. He has pioneered the field of in vivo biochemistry and he has been the leading investigator in the work translating basic science into clinical physiology.