Bernd Giese

Professor of organic chemistry. Cofounder and chairman of the biotech company PIQUR.

Studied the influence of activation entropies on the selectivity of organic reactions, and developed the isoselective relationship. Contributed to the understanding of radical reactions, and developed a modern, stereoselective synthethis method (Giese reaction). Contributed to the understanding of radical induced DNA cleavage and of the DNA synthesis by ribonucleotide reductase. Developed chemical methods of restriction and mismatch detection in DNA. Discovered that charge transfer over long distances in DNA occurs by a hopping mechanism. Studies long distance charge transfer in peptides and the question how microorganisms use this process for the formation of silver nanoparticles. Synthesized molecules that influence signal transduction pathways (c-di-GMP and Piqur 309).