Angelika Amon

Angelika Amon identified how chromosome segregation is achieved and the consequences of chromosome missegregation and aneuploidy on cell physiology and tumorigenesis. Amon established that the central role of a phosphatase (Cdc14) of the final stages of mitosis and elucidated its intricate regulation by nucleolar sequestration. Amon’s work on aneuploidy, a hallmark of cancer, revealed that aneuploidy elicits a systemic stress response characterized by proliferation defects, as well as proteotoxic and energy stress. Amon also identified genetic and chemical interventions that enhance or suppress the aneuploidy-associated stresses providing insights into tumorigenesis and identifying aneuploidy as a therapeutic target.