Angela M. Gronenborn

Gronenborn has developed strategies to study protein-ligand and protein-protein complexes. These methods include, nuclear magnetic resonance (NMR), X-ray crystallography and cryo-electron-microscopy. To integrate NMR into these studies, she has developed new strategies, including 3D and 4D spectroscopy for higher molecular-weight systems, allowing her to determine the solution-structures of many proteins of medical significance. Her quest is to provide a structural understanding how the HIV-1 virus hijacks the machinery of the human host and exploits it for its own replication.